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Triple negative chemo resistant breast cancer

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Metastatic breast cancer also called stage IV or advanced breast cancer is not a specific type of breast cancer. Metastatic breast cancer is breast cancer that has spread beyond the breast and nearby lymph nodes to other parts of the body most often the bones, lungs, liver or brain. For example, breast cancer that has spread to the bones is still breast cancer not bone cancer. It may also be called metastatic breast cancer in the bones or bone metastases.
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Triple negative breast cancers can adopt reversible state that is resistant to chemotherapy

Triple negative chemo resistant breast cancer
Triple negative chemo resistant breast cancer
Triple negative chemo resistant breast cancer
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Triple-Positive Breast Cancer Overview

Because the cancer cells lack these proteins, treatment options for triple-negative breast cancer are limited. Hormone therapy and drugs that target HER2 are not helpful, so chemotherapy is the main systemic treatment option. And although, TNBC tends to respond well to initial chemotherapy, it tends to come back recur more frequently than other breast cancers. If the early-stage TNBC tumor is small enough for surgery then breast-conserving surgery or a mastectomy with a check of the lymph nodes may be done. In certain cases, such as a large tumor or if lymph nodes are found to have cancer, radiation may follow surgery. Because hormone therapy and HER2 drugs are not choices for women with triple-negative breast cancer, chemotherapy is the main systemic option. It might be given before surgery neoadjuvant chemotherapy to shrink a large tumor.
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What Are the Treatment Options for Triple-Negative Breast Cancer (TNBC)?

Triple negative breast cancer is an uncommon type of breast cancer. Read about the symptoms, how it is diagnosed and treated, and what happens after treatment. Your doctor uses a sample of your cancer to test the cells for these receptors. You might have this testing following a biopsy of the cancer, or after surgery to remove it. BRCA1 is one of the gene faults that can increase the risk of breast cancer within families.
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While there is some controversy over triple-positive breast cancer being a distinctive subtype of the disease, these cancers appear to act differently than other breast cancers with regard to both cell behavior and the response to treatment. Knowing the hormone receptor status of your tumor is imperative, because it helps you and your doctor make the best decisions about your treatment course. With triple-positive breast cancer, however, this is often more complicated than it may seem.
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